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Select Try/Buy and follow instructions to begin your free 30-day trial, © 2000–2020 Unbound Medicine, Inc. All rights reserved, TY - ELEC NEXLETOL is indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with HeFH or established ASCVD who require additional lowering of LDL-C. References1 Laufs U, et al. Nexletol is indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who require additional lowering of LDL-C. NEXLETOL is a first-in-class ATP Citrate Lyase (ACL) inhibitor that lowers LDL-C by reducing cholesterol biosynthesis and up-regulating the LDL receptors. Bempedoic acid. Through scientific and clinical excellence, and a deep understanding of cholesterol biology, the experienced Lipid Management Team at Esperion is committed to developing new LDL-C lowering medicines that will make a substantial impact on reducing global cardiovascular disease, the leading cause of death around the world. Any express or implied statements contained in this press release that are not statements of historical fact may be deemed to be forward-looking statements. LDL-C lowering was numerically greater in females compared with males across both pools of the study: The placebo-corrected mean reduction was 27.7% for females vs. 22.1% for males (interaction p value=0.079) in the statin-intolerant pool, and 21.2% for females vs. 17.4% for males (interaction p value=0.044) in the pool of patients with atherosclerotic cardiovascular disease (ASVCD) and/or heterozygous familial hypercholesterolemia (HeFH) who were receiving background maximally tolerated statin. DB - Anesthesia Central Please Sign in with your Anesthesia Central account, Type your tag names separated by a space and hit enter. Pharm. Primary research N = 350 healthcare practitioners, 4 J Tamargo, G Rosano, T Walther, J Duarte, A Niessner, JC Kaski, C Ceconi, H Drexel, K Kjeldsen, G Savarese, C Torp-Pedersen, D Atar, BS Lewis, S Agewall, Gender differences in the effects of cardiovascular drugs, European Heart Journal - Cardiovascular Pharmacotherapy, Volume 3, Issue 3, July 2017, Pages 163–182, https://doi.org/10.1093/ehjcvp/pvw042, Contact:Kaitlyn Brosco Esperioninvestorrelations@esperion.com. Tendon rupture has occurred. "Bempedoic Acid.". What is Nexletol? Nexletol is a first-in-class adenosine triphosphate-citrate lyase (ACL) inhibitor that lowers LDL-C by inhibiting cholesterol synthesis in the liver. Bempedoic acid was generally well tolerated by both sexes.2. Quiring C, Sanoski CA, Vallerand AH. Explore these free sample topics: Anesthesia for Vascular Surgery - Abdominal Aortic Repair, -- The first section of this topic is shown below --, Pharm. Nexletol is a prescription medicine used along with diet and other lipid-lowering medicines in the treatment of adults with: heterozygous familial hypercholesterolemia (HeFH). Look up information on diseases, tests, and procedures; then consult the database with 5,000+ drugs or refer to 65,000+ dictionary terms. This collection of drugs, procedures, and test information is derived from Davis’s Drug, MGH Clinical Anesthesia Procedures, Pocket Guide to Diagnostic Tests, and PRIME Journals. November 2020. *Note: Esperion strives to be inclusive in our both research and our language, and we follow the language guidance outlined in “Reporting Sex, Gender, or Both in Clinical Research?” from The Journal of the American Medicine Association (JAMA). 3 ZS Associates primary and secondary research, Sep-Oct 2018. DP - Unbound Medicine In: * Article titles in AMA citation format should be in sentence-case, You can cancel anytime within the 30-day trial, or continue using anesthesia central 1. temporary class adenosine triphosphate-citrate lyase inhibitors-- To view the remaining sections of this topic, please sign in or purchase a subscription--General . Assess uric acid levels periodically as clinically indicated. Class. Any forward-looking statements contained in this press release speak only as of the date hereof, and Esperion disclaims any obligation or undertaking to update or revise any forward-looking statements contained in this press release, other than to the extent required by law. November 2020. Class. Monitor for signs and symptoms of hyperuricemia, and initiate treatment with urate-lowering drugs as appropriate. In these studies, NEXLETOL provided an average of 18% placebo-corrected LDL-C lowering when used with moderate or high-intensity statins. ET - 16 2 Goldberg AC, et al. Want to see more products from Unbound Medicine. Bempedoic acid blocks an enzyme in the liver called adenosine triphosphate citrate lyase, which is involved in making cholesterol. Pronunciation: bem-pe-doe-ik as-id. - Significant mean reduction of 26.5% in LDL-C with bempedoic acid vs. placebo in pooled analysis of people who cannot tolerate statins1 -, - Analysis by sex showed bempedoic acid significantly lowered LDL-C at week 12 in males and females* vs. placebo2 -. Forward-looking statements involve risks and uncertainties that could cause Esperion's actual results to differ significantly from those projected, including, without limitation, delays or failures in Esperion’s clinical development and commercialization plans, or approval of expanded indications, that existing cash resources may be used more quickly than anticipated, the impact of COVID-19 on our business, clinical activities and commercial development plans, and the risks detailed in Esperion's filings with the Securities and Exchange Commission. In. lipid-lowering agents. Presentation at the American Heart Association Virtual Scientific Sessions 2020. NEXLETOL was generally well tolerated, with treatment-emergent adverse events (TEAEs) comparable across the bempedoic acid and placebo groups.1, The poster “Efficacy and Safety of Bempedoic Acid by Sex: Pooled Analyses From Phase 3 Trials” (Abstract #P742) showed NEXLETOL significantly lowered LDL-C at week 12 in both sexes compared with placebo for a pooled population of more than 3,600 patients across four studies. bempedoic acid is a topic covered in the Davis's Drug Guide.. To view the entire topic, please sign in or purchase a subscription.. NEXLETOL was approved by the FDA in February 2020. AU - Sanoski,Cynthia A, Efficacy and Safety of Bempedoic Acid in Patients who Cannot Tolerate Any Does of a Statin: Pooled Analysis from Phase 3 Clinical Trials. Statements of historical fact may be deemed to be forward-looking statements cholesterol called low density lipoprotein ( LDL.! Download the Anesthesia Central is an award-winning, complete mobile solution for treating patients,. Procedures ; then consult the database with 5,000+ drugs or refer to dictionary! Who have a history of tendon rupture historical fact may be deemed to be forward-looking statements patients before during. - 16 DB - Anesthesia Central app by Unbound Medicine ER -, Quiring C.... Drugs to the FDA, ET al by Sex: Pooled Analyses From 3. Discontinue NEXLETOL® ( bempedoic acid blocks an enzyme in the Davis 's Drug Guide called triphosphate! This entry is available only to subscribers of 18 % placebo-corrected LDL-C lowering when used with moderate high-intensity. As appropriate for NEXLETOL by clicking here & Vallerand, A. H. ( 2020 ) Courtney... First-In-Class adenosine triphosphate-citrate Lyase ( ACL ) inhibitor that lowers LDL-C by inhibiting cholesterol synthesis the. Nexletolamong others, is a topic covered in the Davis 's Drug Guide of 18 % placebo-corrected LDL-C when. And mobile solution for treating patients before, during, and procedures then! 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