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WebMD does not provide medical advice, diagnosis or treatment. Grapefruit juice-simvastatin interaction : Effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors Author LILJA, J. J; KIVISTÖ, K. T; NEUVONEN, P. J Department of Clinical Pharmacology, University of Helsinki, and Helsinki University Central Hospital, Finland Source. Food Interactions With Simvastatin (Zocor) Food interactions include grapefruit juice and alcohol. Continue to follow the cholesterol-reducing diet recommended by your health care provider. Drug interactions are reported among people who take Simvastatin and Flecainide acetate. Background: Soluble fiber supplements are recommended to reduce levels of low-density lipoprotein cholesterol (LDL-C). Major Food Interaction. Drug interaction with any of these substances may enhance or decrease the effect of Ezetimibe. It is recommended that you avoid taking Simvastatin with large amounts of grapefruit juice. Action . It is recommended that you avoid taking Simvastatin with large amounts of grapefruit juice. Epub 2012 Dec 5. Simvastatin has the following interaction information: Alcohol. Food-drug interactions: effect of capsaicin on the pharmacokinetics of simvastatin and its active metabolite in rats. Promptly consult your doctor or pharmacist. Zhai XJ(1), Chen JG, Liu JM, Shi F, Lu YN. MONDAY, Oct. 17, 2016 (HealthDay News) -- Cholesterol-lowering statins can interact with other drugs prescribed for … 40 mg of zocor at night and half an aspirian. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Grapefruit juice can significantly increase the blood levels of simvastatin. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. It is also used in the treatment of long-term complications such as heart disease or stroke. May enhance hepatic side hepatic effects with alcohol. Food-drug interactions: effect of capsaicin on the pharmacokinetics of simvastatin and its active metabolite in rats Food Chem Toxicol. In some cases, rhabdomyolysis can cause kidney damage and even death. For non-prescription products, read the label or package ingredients carefully. Moderately clinically significant. Do not stop using any medications without first talking to your doctor. Simvastatin is usually taken in the evening or at bedtime. The study is created by eHealthMe based on reports of 271 people who take Simvastatin and Flecainide acetate from the FDA, and is updated regularly. simvastatin ↔ food. The interaction has also been reported with lovastatin, which has a similar metabolic profile to simvastatin. Simvastatin is used to reduce the level of bad cholesterol in the body. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Do not stop using any medications without first talking to your doctor. History. Minimally clinically significant. Both simvastatin and alectinib can increase the risk of hepatotoxicity. Common interactions include abdominal symptom among females and palpitations among males. © 2005 - 2019 WebMD LLC. Dr. Joan Woo answered. Continue to follow the cholesterol-reducing diet recommended by your health care provider. simvastatin is now contraindicated with ciclosporin, danazol and gemfibrozil the maximum recommended dose for simvastatin in conjunction with amlodipine or diltiazem is now 20 mg/day A … Drug interactions are reported among people who take Simvastatin and Flecainide acetate. Very Important. What you should do about this interaction: While you are taking this medicine, do not eat grapefruit or drink grapefruit juice at any time. A change in your diet, medicine, or dosage may be necessary. Both simvastatin and alcohol can increase the risk of hepatotoxicity. 2013 Mar;53:168-73. doi: 10.1016/j.fct.2012.11.045. It is also used in the treatment of long-term complications such as heart disease or stroke. Common side effects of Zocor include headache, nausea, vomiting, diarrhea, abdominal pain, muscle pain, abnormal liver tests, hypersensitivity reactions, memory loss, forgetfulness, amnesia, confusion, and memory impairment. Major Food Interaction Consumer information for this interaction is not currently available. Drug interaction with any of these substances may enhance or decrease the effect of Rosuvastatin. Zetia, atorvastatin, Jardiance, Brilinta, fenofibrate, Lopid, Xarelto, rosuvastatin, Lipitor, Crestor. Other Interactions . There are 263 drug interactions with simvastatin. Find everything you need to know about Zocor (Simvastatin), including what it is used for, warnings, reviews, side effects, and interactions. Selected from data included with permission and copyrighted by First Databank, Inc. Simvastatin: Belongs to the class of HMG CoA reductase inhibitors. CAP (3, 8 or 25 mg/kg), ketoconazole, dexamethasone or 5% CMC-Na was … 18 years experience Cardiology. A change in your diet, medicine, or dosage may be necessary. Food-drug interactions: effect of capsaicin on the pharmacokinetics of simvastatin and its active metabolite in rats Food Chem Toxicol. Things to remember when you fill your prescription. WebMD provides information about interactions between Simvastatin Oral and avoid-grapefruit-unless-md-instructs-otherwise. Alectinib. but pulse dropped into the high 40s about 4 hours ago and is still hovering between 48 and 52. taking 120 mg of diltiazem every morning. We comply with the HONcode standard for trustworthy health information -. Simvastatin and niacin work together to treat cholesterol and lipid (fat) disorders. April 1, 2020 Update: The Food and Drug Administration (FDA) announced the recall of all medications containing the ingredient ranitidine, known by the brand name Zantac. Zocor (simvastatin) is a statin drug that lowers total cholesterol, LDL cholesterol (bad cholesterol), and triglycerides, and boosts HDL cholesterol (good cholesterol). Provides a summary of interactions with vitamins, herbs, and food Take simvastatin oral suspension (liquid) on an empty stomach. Avoid grapefruit juice while taking simvastatin. GENERALLY AVOID: Coadministration with grapefruit juice may significantly increase the plasma concentrations of lovastatin and simvastatin and their active acid metabolites. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. A member asked: heart concerns history of afib....bp is 120 over 75. no pain. Usually avoid combinations; use it only under special circumstances. There are 2 alcohol/food/lifestyle interactions with simvastatin which include: Simvastatin may cause liver problems and using it with substantial quantities of ethanol may increase that risk. Food-drug interactions: effect of capsaicin on the pharmacokinetics of simvastatin and its active metabolite in rats. It is important to know if you need to avoid any Food, Herbs, or Alcohol when taking Rosuvastatin. Consuming alcohol with statins increases your chances of developing liver toxicity, and statins should be avoided altogether if you have alcoholic hepatitis. simvastatin ↔ food. Grapefruit and grapefruit juice may interact with simvastatin and lead to potentially dangerous effects, including muscle injury. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Drug interaction with any of these substances may enhance or decrease the effect of Rosuvastatin. Simvastatin has the following interaction information: Alcohol. For example, if a 20-mg dose is administered, only 1 mg reaches the systemic circulation. Food Interactions With Simvastatin (Zocor) Food interactions include grapefruit juice and alcohol. Should I avoid certain foods while taking Simvastatin? Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. Simvastatin is a sensitive CYP3A4 substrate and ceritinib is a strong CYP3A4 inhibitor. Are Statin Side Effects 'All in Your Head'? Simvastatin, sold under the brand name Zocor among others, is a lipid-lowering medication. Clinical pharmacology and therapeutics. One of the unique properties of simvastatin is very low bioavailability (<5%) due to high firstpass metabolism. Eat like a Mediterranean. Avoid combinations; the risk of the interaction outweighs the benefit. Zhai XJ(1), Chen JG, Liu JM, Shi F, Lu YN. It is important to know if you need to avoid any Food, Herbs, or Alcohol when taking Atorvastatin. Amiodarone. Manufacturer advises adjust simvastatin dose. Simvastatin Food Interactions. Chlorzoxazone: (Moderate) One case report has noted a possible drug interaction between simvastatin and chlorzoxazone. Inform MD. This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue. The study is created by eHealthMe based on reports of 271 people who take Simvastatin and Flecainide acetate from the FDA, and is updated regularly. Discuss the use of grapefruit products with your doctor. HealthDay Reporter. It is important to know if you need to avoid any Food, Herbs, or Alcohol when taking Atorvastatin. All rights reserved. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. A proper diet and regular exercise should be maintained along with taking this medicine. Should I avoid certain foods while taking Niacin-Simvastatin Tablet, Extended Release Multiphase 24 Hr (Tablet, ER Hr)? Other Interactions . GENERALLY AVOID: Coadministration with grapefruit juice may significantly increase the plasma concentrations of lovastatin and simvastatin and their active acid metabolites. How Long Does Coronavirus Live On Surfaces? Increased plasma concentrations resulting to increased risk of myopathy and rhabdomyolysis with grapefruit juice. Background: Soluble fiber supplements are recommended to reduce levels of low-density lipoprotein cholesterol (LDL-C). Severity of interaction: Severe Evidence … Before taking simvastatin, tell your doctor about all of your medical conditions. There are 6 disease interactions with simvastatin which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Available for Android and iOS devices. Check out the following foods to eat (and avoid) for lower cholesterol numbers and a cleaner bill of health. 6.Li S, Yu Y, Jin Z, Dai Y, Lin H, Jiao Z, Ma G, Cai W, Han B, Xiang X. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. It is important to know if you need to avoid any Food, Herbs, or Alcohol when taking Rosuvastatin. This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue. 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