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1 Effect 2 Notes 3 Interactions 4 Synergies 5 Trivia 5.1 Bugs Isaac appears demonic with large curved horns and an angry expression. Credits: Wofsaugehttp://steamcommunity.com/id/Wofsauge/myworkshopfiles/?appid=250900. In original Binding of Isaac, picking up Brimstone will multiply Isaac's current damage by 3. The 10 best Seeds in The Binding of Isaac Rebirth Each new round in the Binding of Isaac has to be documented in a own Seed, with the certain random Event like the Item distribution. Whichever it is the correct one has that Seed with Chain Lightning tears within the first 2 floors. Press question mark to learn the rest of the keyboard shortcuts.
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